During the Second World War, an American Pilot stationed in England meets a young British nurse during an air raid on London. The two instantly fall in love, despite the fact that the young Nurse is already married; a secret she keeps hidden from her American lover. After being shot down behind enemy lines, while being assigned to ferry a British agent into France, the American pilot realizes that his secret agent cargo is in fact his lover's husband, and that the two must now work together in order to survive.

The moon rises at a predestined angle and awakens the sleeping Dr. Phibes three years later. To his dismay, he finds his house has been demolished and his papyrus scrolls stolen, the scrolls he needs to find the Pharoah's Tomb in Egypt, where the River of Life flows. After identifying the source of the papyrus theft, he packs and leaves for Egypt with his assistant Vulnavia, still intent upon awakening his dead wife Victoria. The parties responsible for the theft of Phibes' scrolls suffer an attrition problem as Inspector Trout chases him across the world.